Depakote is the brand name for divalproex sodium (also known as valproic acid), an anti-seizure drug used to treat epilepsy, some mood disorders (like bipolar disorder), and migraine headaches. Migraine is a medical condition. Most people who suffer from migraines get headaches that can be quite severe. A migraine headache is usually an intense, throbbing pain on one, or sometimes, both sides of the head. Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Valproic acid and its derivative, divalproex, are oral drugs that are used for the treatment of convulsions, migraines and bipolar disorder. Read 186 reviews of Botox for Migraines, including cost and before and after photos, submitted by members of the RealSelf community. Divalproex sodium occurs as a white powder with a characteristic odor. Depakote ER 250 and 500 mg tablets are for oral administration. Depakote ER tablets contain divalproex sodium in a once-a-day extended-release formulation equivalent to 250 and 500 mg of valproic acid. What other drugs will affect Depakote? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. How to Deal With Migraines. Fevers, the flu, sinus infections, stress and tension can all trigger headaches, which cause a dull throb in your head. However, migraine headaches are different. Physicians describe them as recurrent headaches. Mania. Depakote (divalproex sodium) is a valproate and is indicated for the treatment of the manic episodes associated with bipolar disorder. A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. Fioricet® (butalbital, acetaminophen, caffeine)* Fioricet® is for mild to moderate Migraine pain management. Migraineurs find Fioricet® is a useful therapy when taken before lying down in a dark room because it is compounded with a barbiturate (used for its sedative effects).